What Is Lupus?

downloadTypes of Lupus

Discoid Lupus (also Cutaneous Lupus) is confined to the skin. It is characterized by persistent flushing of the cheeks or disk-like lesions (i.e. rash) that appear on the face, neck, scalp and other areas exposed to ultraviolet light (sunlight, fluorescent light). The rash is usually raised, scaly red but not itchy. These lesions, if not adequately treated, may develop into permanent scars. If they involve the scalp, they can result in bald spots.

Systemic Lupus Erythematosus (SLE)  is a chronic disorder of the immune system that causes inflammation of various parts of the body. For most people, lupus is mild, affecting only a few body organs: for others, it may cause serious and life threatening problems. The body’s immune system normally makes proteins called antibodies to protect the body against viruses, bacteria and other foreign materials. These foreign materials are called antigens. In an immune disorder such as lupus, the immune system loses the ability to tell the difference between foreign substances (antigens) and its own cells and tissues. The immune system then makes antibodies directed against “self”. These antibodies react with the “self” antigen to form immune complexes. The immune complexes build up in the tissues and can cause inflammation, injury to tissues and pain.

Drug-Induced Lupus is the result of certain prescribed drugs. These medications can create a lupus-like syndrome which is similar to SLE, but very rarely affects either the kidneys or the nervous system. The most commonly implicated drugs are hydralazine (used to treat hypertension) and procainamide (used to treat irregular heart rhythms). Drug-induced lupus is more common in men than women because they are treated with these drugs more often than women. However, only about four percent of the individuals who take these drugs will develop the antibodies of lupus and an even smaller percentage will actually develop drug-induced lupus. When the medication is stopped, lupus symptoms usually fade. To read more about Drug Induced Lupus and about what drugs are commonly thought to cause Drug Induced Lupus click here.

Neonatal Lupus is a rare autoimmune disorder that is present at birth and affects infants of women who have lupus and/or Anti-Ro/SSA Antibodies. Affected infants often develop a red rash, may develop liver problems and low blood platelets. Some infants also develop a heart condition known as congenital heart block. The symptoms associated with neonatal lupus, with the exception of congenital heart block, usually resolve themselves within the first several months of life.

Who Gets Lupus?

There are 1.5 million people in the United States who suffer from systemic lupus. More people have lupus than cerebral palsy, multiple sclerosis, sickle-cell anemia and cystic fibrosis combined.

Young women are most frequently affected, out-numbering male patients ten to one. The onset of lupus occurs most often in persons 20-40 years of age, but can occur at any time.

African Americans and Hispanics have a higher frequency (as high as three times more) of this disease than do Caucasians. SLE also appears in the first-degree relatives of lupus patients more often than it does in the general population, which indicates a strong hereditary component. However, most cases of SLE occur sporadically, indicating that both genetic and environmental factors play a role in the development of the disease.

About 5 percent of the children born to individuals with lupus will develop the illness.


Source: Larry Silverman, M.D. F.A.C.P., F.A.C.R. and National Institute of Health